Pan-Cancer Analyses Refine the Single-Cell Portrait of Tumor-Infiltrating Dendritic Cells.

ABSTRACT: Dendritic cells (DC) are pivotal orchestrators of antitumor immunity. DC-based antitumor treatments are being actively developed, but effective clinical responses have not yet been achieved. Further exploration of DC heterogeneity in the tumor microenvironment and across cancer types could provide insights for developing DC-based immunotherapies. In this study, we integrated single-cell RNA sequencing data of DCs from more than 2,500 samples across 33 cancer types and established a comprehensive blueprint of human DCs. Several rare subsets of DCs infiltrated the tumors, including AXL+SIGLEC6+ DCs and Langerhans cell-like DCs, and displayed functional potentials marked with distinct transcriptomic characteristics. Computational analyses demonstrated that the Langerhans cell-like subset coul

SUBMITTER: Ma T 

PROVIDER: S-EPMC12485386 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature