Lunar life drives jawbone formation.

ABSTRACT:

Background/purpose

The Japan Aerospace Exploration Agency bred mice in the "Kibo" module on the International Space Station to clarify the effects of gravity changes on the body. We determined the effects of lunar gravity (partial gravity, 1/6G) on the jawbone and elucidated its relationship with the oral cavity.

Materials and methods

Mandibular bones of C57BL/6J male mice from the Kibo group (1/6G) and the Earth group (1G) were obtained. Ribonucleic acid was extracted from the samples; microarray and gene set enrichment analysis (GSEA) were performed; bone structure and histology were evaluated via micro-computed tomography, immunohistochemistry, and specific staining.

Results

Microarray analysis revealed a significant increase in dentin matrix protein 1 (DMP1) expre

SUBMITTER: Sato K 

PROVIDER: S-EPMC12485402 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature