Trends in non-opioid analgesic use following major abdominal surgery: a retrospective single-center cohort study.

ABSTRACT:

Background

Non-opioid analgesics are essential in multimodal analgesia and opioid-sparing strategies; however, their clinical use remains suboptimal. This study aimed to investigate trends in perioperative non-opioid analgesic administration and associated adverse effects in patients undergoing major abdominal surgery at a tertiary hospital.

Methods

Prescription data for acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) were retrospectively collected from January 2020 to December 2024. Actual administration was assessed at three perioperative phases: preemptive, intraoperative, and postoperative (postoperative day [POD] 0-3). The study period was divided into 20 quarters. Trends of administration rates over time were analyzed using a linear regression model. P

SUBMITTER: Yoon SH 

PROVIDER: S-EPMC12485472 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature