Low/High Multi-Frequency Stimulation of the Subthalamic Nucleus Improves Verbal Fluency Maintaining Motor Control in Parkinson's Disease.

ABSTRACT:

Background

High frequency deep brain stimulation of the subthalamic nucleus (STN-DBS) is a well-established therapy for Parkinson's disease (PD) motor symptoms, however, its effect on non-motor symptoms is controversial. Low frequency DBS can improve cognition, but its effects on motor functions are detrimental.

Objective

Our goal was to evaluate the effect on verbal fluency (VF) of dual frequency STN-DBS combining high and low frequency (130 + 10 Hz) as compared to 130 Hz or 10 Hz alone and to OFF stimulation. The effect on motor symptoms, working memory, and subjective feelings was also assessed.

Methods

We used a randomized order of experimental conditions with a double-blind design to assess the effects of 130 Hz, 10 Hz, and 130 + 10 Hz stimulation as compared to

SUBMITTER: Ricciardi L 

PROVIDER: S-EPMC12485583 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature