Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders.

ABSTRACT:

Background

Excessive daytime sleepiness (EDS) is a disabling symptom of Lewy body disorders (LBD). The hypothalamus is a key sleep-wake regulator and is involved in Lewy pathology, but its contribution to EDS in LBD remains unclear.

Objectives

To use diffusion-weighted magnetic resonance imaging (MRI) to detect hypothalamic microstructure and determine its relationship to EDS symptoms in LBD in an exploratory investigation.

Methods

We studied 102 patients with clinically defined LBD (Parkinson's disease [PD], n = 93; PD dementia, n = 4; and dementia with Lewy bodies, n = 5) and Epworth Sleepiness Scale (ESS) within 2 years of MRI. Mean diffusivity (MD) was compared between EDS+ (ESS ≥ 10, n = 37) and EDS- (ESS < 10, n = 65) groups in three hypothalamic subregions, cov

SUBMITTER: Cohen JS 

PROVIDER: S-EPMC12485596 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature