Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke.

ABSTRACT:

Importance

The cumulative burden of chronic vascular and neurodegenerative changes contributes to brain frailty, which may reduce the brain's capacity to recover from acute ischemic stroke (AIS). The association between brain frailty markers and poststroke outcomes after thrombolysis is unclear.

Objective

To evaluate associations between brain frailty assessed on non-contrast-enhanced computed tomography (NCCT) and magnetic resonance imaging (MRI) and functional outcome in patients with AIS treated with intravenous thrombolysis.

Design, setting, and participants

This cohort study was a post hoc analysis of the Alteplase compared to Tenecteplase (AcT) trial, an investigator-led, registry-linked, parallel-group, open-label, randomized clinical trial that enrolled patien

SUBMITTER: Loewen SP 

PROVIDER: S-EPMC12485648 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature