Cross-Modality Comparison of Fetal Brain Phenotypes: Insights From Short-Interval Second-Trimester MRI and Ultrasound Imaging.

ABSTRACT: Advances in fetal three-dimensional (3D) ultrasound (US) and magnetic resonance imaging (MRI) have revolutionized the study of fetal brain development, enabling detailed analysis of brain structures and growth. Despite their complementary capabilities, these modalities capture fundamentally different physical signals, potentially leading to systematic differences in image-derived phenotypes (IDPs). Here, we evaluate the agreement of IDPs between US and MRI by comparing the volumes of eight brain structures from 90 subjects derived using deep-learning algorithms from majority same-day imaging (days between scans: mean = 1.2, mode = 0 and max = 4). Excellent agreement (intra-class correlation coefficient, ICC>0.75$$ ICC>0.75 $$ ) was observed for the cerebellum, cavum septum pellucidum, thal

SUBMITTER: Wyburd MK 

PROVIDER: S-EPMC12485670 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature