Integrative analysis reveals generalizable human neurodegenerative disease-associated glial states.

ABSTRACT: Disease-associated glia represent plastic transcriptional cellular states observed across neurodegenerative diseases (NDDs). In particular, microglial states have been characterized in Alzheimer's disease and mouse models of amyloidosis. Although single-cell transcriptomic technologies have increased the dimensionality of information available across cell states, few studies have systematically tested for changes in glial transcription across brain regions and disease states. Here, we report a statistical framework for glial annotation, disease association, and transcriptional profiling, which facilitate identification of generalizable glial states that are present across a spectrum of NDDs (Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Frontotemporal dementi

SUBMITTER: Horan-Portelance L 

PROVIDER: S-EPMC12485690 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature