Low affinity noradrenergic signaling promotes passive coping during reinforcement behavior.

ABSTRACT: During stress and in many psychiatric disorders the ability to appropriately recognize and respond to cues to avoid negative outcomes (e.g., injury) and achieve positive outcomes (e.g., food) is disrupted. A critical component of the stress response is increased noradrenergic tone, acting on lower affinity noradrenergic receptors (α1 and β). Noradrenergic signaling is essential for cue-driven behavior, yet how noradrenergic components of the stress response impacts positive and negative reinforcement behavior is still unknown. We manipulated noradrenergic receptor (α1, α2, and β) activity during an active avoidance and reward seeking task in male and female rats. We found modulating noradrenergic activity on low affinity α1 and β receptors but not α2 receptors disrupted reinforcement behav

SUBMITTER: Rodberg EM 

PROVIDER: S-EPMC12485757 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature