Neuroanatomical Correlates of Negative Symptoms in Schizophrenia.

ABSTRACT:

Background

Schizophrenia is characterized by widespread structural brain abnormalities, but associations between structural abnormalities and negative symptom severity are not well understood. Negative symptoms have been conceptualized in a hierarchical structure of two second-order dimensions-motivation and pleasure (MAP) and expression (EXP)-and five first-order domains: anhedonia, avolition, and asociality (MAP), and blunted affect and alogia (EXP). A better understanding of the neural circuitry underlying negative symptom dimensions and domains is important given their reported association with poor functional outcome and lack of available treatments.

Study design

The meta-analysis included 1,591 individuals with schizophrenia across 16 samples with structural imaging an

SUBMITTER: Kamalakannan SMV 

PROVIDER: S-EPMC12485849 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature