Insulin deficiency inhibits vaccine-mediated antibody and germinal center B-cell formation in mice.

ABSTRACT: Individuals with diabetes are at increased risk for severe outcomes from vaccine-preventable infections and often mount weaker immune responses to vaccination. The diabetes-related factors underlying this impaired immunity remain unclear, but defining them is critical for improving vaccine strategies in this vulnerable population. Here, we isolated insulin deficiency as a contributing factor to decreased vaccine-mediated immune responses using a mouse model. Following immunization with an alum-adjuvanted protein subunit vaccine, insulin-deficient mice exhibited reduced antigen-specific IgG antibody responses, decreased B-cell and T-cell numbers, and lower germinal center B-cell counts within the vaccine-draining lymph node. Three-dimensional whole-organ light sheet microscopy combined with

SUBMITTER: Genito CJ 

PROVIDER: S-EPMC12485872 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature