Sources of outdoor air pollution exposure and child brain network development across the United States.

ABSTRACT: Ambient fine particulate matter (PM_2.5) pollution is a heterogeneous mixture of chemicals with documented neurotoxic effects. Developmental neuroimaging literature has linked childhood PM_2.5 exposure to alterations in brain morphology, microarchitecture, and function, with implications for cognition and psychopathology. However, the extant literature remains largely cross-sectional and often considers PM_2.5 a single pollutant, rather than a heterogeneous mixture of chemicals from different sources. This work addresses these gaps by leveraging estimates of exposure to six PM_2.5 sources derived from positive matrix factorization, and longitudinal neuroimaging data from a large, geographically-diverse sample of Adolescent Brain Cognitive Development

SUBMITTER: Bottenhorn KL 

PROVIDER: S-EPMC12485905 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature