Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels.

ABSTRACT: The ion channel (IC) genes encoded in the human genome play fundamental roles in cellular functions and disease and are one of the largest classes of druggable proteins. However, limited knowledge of the diverse molecular and cellular functions carried out by ICs presents a major bottleneck in developing selective chemical probes for modulating their functions in disease states. The wealth of sequence data available on ICs from diverse organisms provides a valuable source of untapped information for illuminating the unique modes of channel regulation and functional specialization. However, the extensive diversification of IC sequences and the lack of a unified resource present a challenge in effectively using existing data for IC research. Here, we perform integrative mining of available s

SUBMITTER: Taujale R 

PROVIDER: S-EPMC12485921 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature