Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate.

ABSTRACT: Human cortical neurogenesis involves conserved and specialized developmental processes during a restricted window of prenatal development. Radial glia (RG) neural stem cells shape cortical cell diversity by giving rise to excitatory neurons, oligodendrocytes, and astrocytes, as well as olfactory bulb interneurons (INs) and a recently characterized population of cortical INs^1,2. Complex genetic programs orchestrated by transcription factor (TF) circuits govern the balance between self-renewal and differentiation, and between different cell fates^3-8. Despite progress in measuring gene regulatory network activity during human cortical development^9-12, functional studies are required to evaluate the roles of TFs and effector genes in human RG lineage progressio

SUBMITTER: Ding JW 

PROVIDER: S-EPMC12485932 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature