Convergent and divergent neural and behavioral responses to chronic cocaine use in macaques.

ABSTRACT: Chronic cocaine use leads to physical dependence, psychological addiction, and various health problems such as cardiovascular issues and cognitive impairments. This condition continues to be extremely difficult to treat, as we grapple with its neural and behavioral complexities. What we are missing is a comprehensive account on how naïve brains react to occasional and chronic cocaine use, abstinence and re-exposure within subject. We tracked naïve macaques using precision functional mapping before, during and after chronic cocaine self-administration over a period of nine months. We analyzed the entire brain to illustrate the pervasive impact of chronic cocaine use on overall function. Although we set out to map the "addiction" connectome, we found that the neural correlates of chronic dru

SUBMITTER: Manea AMG 

PROVIDER: S-EPMC12485942 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature