Multimodal Neuroimaging Signature of Sleep Problems Predicts Preadolescent Mental Health Trajectories.

ABSTRACT: Sleep-related problems (SRP) in childhood are common and clinically relevant yet their underlying neural mechanisms and links to future mental health outcomes remain poorly understood. Here, we investigated how distinct dimensions of SRP relate to multimodal brain structure and function in preadolescents, and whether these neural signatures predict trajectories of mental health difficulties. We employed multivariate mapping to investigate the relationship between structural and functional brain network patterns and various dimensions of SRP in the Adolescent Brain Cognitive Development (ABCD) dataset. Moreover, we explored whether and how the identified multimodal brain signatures could predict the trajectory of internalizing and externalizing behavior difficulties over a two-year follow-u

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12485969 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature