Tracking a decade of structural changes in preclinical and prodromal Alzheimer's disease: insights from amyloid-β pathology.

ABSTRACT: Alzheimer's disease (AD) pathology is typically associated with reduced brain volume and cortical thickness, interpreted as neurodegeneration. However, several cross-sectional studies in cognitively unimpaired individuals have paradoxically reported larger brain volume and thicker cortex in the presence of amyloid-β (Aβ), suggesting that Aβ-brain structure associations may not follow a simple linear pattern early in the disease. We leveraged over a decade of longitudinal data from the PREVENT-AD cohort (N=367, mean follow-up 7.17 years, range 0-11.27 years) to investigate how Aβ burden related to both cross-sectional levels and longitudinal changes in brain volume, cortical thickness, and cortical tissue mean diffusivity (MD _T ) derived from free-water corrected diffusion tensor

SUBMITTER: Qiu T 

PROVIDER: S-EPMC12485976 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature