Brain Health Loss Mediates the Effect of Infarct Volume on Functional Outcome in Ischemic Stroke.

ABSTRACT:

Importance

Brain health may facilitate resilience to detrimental consequences from neurological diseases. Infarct volume is associated with poor functional outcome after acute ischemic stroke (AIS), but potential mediating effects through stroke-related brain health loss have not been investigated.

Objective

To determine whether stroke-related brain health loss, quantified by change in MRI derived effective Reserve (eR), mediates the effect of acute infarct volume on functional outcome after AIS.

Design

Observational multicenter cohort study.

Setting

We analyzed data from the GASROS (n=488) and MRI-GENIE (n=560) cohorts, collected 2003-2011.

Participants

Adult patients consecutively diagnosed with AIS, with available admission MRI.

Exposure

At adm

SUBMITTER: Lindgren E 

PROVIDER: S-EPMC12485999 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature