Omega-6 polyunsaturated fatty acids and adiposity in the UK Biobank Cohort: a cross-sectional and longitudinal prospective analysis.

ABSTRACT:

Background

The role of omega-6 polyunsaturated fatty acids (PUFAs), especially linoleic acid (LA) in adiposity remains contested. While clinical interventions suggest improved body composition with higher LA intake, observational evidence is inconsistent, and few studies incorporate repeated measures to examine longitudinal change.

Objective

To investigate associations of circulating LA, non-LA omega-6, and total omega-6 PUFAs with adiposity outcomes in the UK Biobank.

Methods

Multivariable linear models evaluated cross-sectional and longitudinal associations between omega-6 fatty acid levels and waist circumference (WC), weight, and whole-body fat mass (FM) adjusting for relevant demographic, lifestyle and medical history covariates. Models considered FA levels per i

SUBMITTER: Lai HTM 

PROVIDER: S-EPMC12486028 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature