Viscoelastic properties of tumor spheroids revealed by a microfluidic compression device and a modified power law model.

ABSTRACT: Clinically, palpation is one of the important diagnostic methods to assess tumor malignancy. In laboratory research, it is well accepted that the bulk stiffness of the tumor and the surrounding tissue is closely correlated with the malignant state of the tumor. Here, we postulate that, in addition to tumor stiffness, tumor viscoelasticity - the fact that tumor tissue takes time to bounce back after compression, can also be used to evaluate the tumor malignancy state. In this work, we characterized the viscoelastic properties of breast tumor spheroids using a recently developed microfluidic compression device and a theoretical power law model. Breast tumor cells at varying malignant levels; a non-tumorigenic epithelial (MCF10A), moderately malignant tumor (MCF7) and triple negative metastat

SUBMITTER: Pandey M 

PROVIDER: S-EPMC12486062 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature