Research advancements regarding the relationship between FBXO2 and malignant tumors (Review).

ABSTRACT: The ubiquitin‑proteasome system (UPS) acts as a central regulator for a range of protein components, including ubiquitin, ubiquitin‑activating enzyme (E1), ubiquitin‑conjugating enzyme (E2), ubiquitin ligase (E3), the 26S proteasome and deubiquitinating enzyme. These components function in a coordinated manner to facilitate the repair and degradation of proteins. Among the ubiquitinating enzymes, in conjunction with E1‑activating enzymes and E2‑binding enzymes, it attaches to substrates and promotes the transfer of ubiquitin molecules to target proteins. The S‑phase kinase‑associated protein 1 (SKP1)‑Cullin‑F‑box (SCF) complex is one of the E3 ligases involved in cancer progression, and consists of four primary components: i) SKP1; ii) Cullin 1/coiled‑coil domain containing 53; iii) ring b

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12486197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature