Development of Sustainable Biocatalytic Furfurylamine Production in a Magnetic Field-Assisted Microfluidic Reactor.

ABSTRACT: The increasing demand for furfurylamine (FA), a versatile biobased building block, necessitates the development of efficient and sustainable production processes. This study presents a continuous biocatalytic process for the amination of furfural (FUR) to FA, aligning with green chemistry principles and circular economy strategies. A systematic screening of ω-transaminases (ω-TAs) and amine donors identified N-His₆-ATA-wt and (S)-(-)-α-methylbenzylamine as the optimal pair, achieving a 96% FA gross yield within 30 min at equimolar substrate concentrations, surpassing previously reported ω-TA-based FA productions. To enable biocatalyst long-term use in continuous processes, the enzyme was covalently immobilized on synthesized and functionalized magnetite nanoparticl

SUBMITTER: Bozinovic M 

PROVIDER: S-EPMC12486436 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature