Longitudinal interaction between muscle impairments and gait pathology in growing children with Duchenne muscular dystrophy.

ABSTRACT:

Background

Children with Duchenne muscular dystrophy (DMD) present with progressive gait pathology due to progressive muscle weakness and contractures. However, the associations between specific muscle impairments and specific gait features have never been quantified. Therefore, the aim of this longitudinal observational cohort study was to investigate the longitudinal interaction between progressive muscle impairments and progressive gait pathology in growing boys with DMD.

Methods

Thirty-one boys with DMD (aged 4.6-16.4 years) were repeatedly measured between 2015 and 2022, resulting in a total dataset of 152 observations. Fixed dynamometry, goniometry and 3D gait analysis were used to assess lower limb muscle weakness, passive range of motion and gait. Joint random-effect

SUBMITTER: Vandekerckhove I 

PROVIDER: S-EPMC12486530 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature