Xiaoyaosan modulates gut-brain metabolic pathways and brain microstructure in depression: a multi-omics insight.

ABSTRACT:

Background

Depression is closely associated with metabolic disorders in the gut-brain axis. Our previous studies using antibiotics (ABX)-treated mice and germ-free mice models demonstrated that Xiaoyaosan (XYS) alleviates depression by modulating metabolic pathways involved in gut-brain interactions. However, the key metabolic pathways remain to be fully characterized.

Study design

We enriched relevant metabolic pathways and analyzed the correlation between depressive-like behaviors and these pathways. We investigated the effects of XYS on metabolic pathways associated with chronic restraint stress (CRS)-induced depression and innovatively incorporated spatial dimension analysis. We further investigated the impact of these metabolic differences on brain microstructure in dep

SUBMITTER: Hao WZ 

PROVIDER: S-EPMC12486543 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature