Navigating the blood-brain barrier to blood-brain tumor barrier transition: microvascular P-glycoprotein and CD146 potentially contribute to glioma grading.

ABSTRACT:

Background

Adult-type diffuse gliomas are highly vascular malignant tumors of the central nervous system (CNS), classified according to the 2021 WHO CNS criteria. Their neovasculature arises through both angiogenesis and vascular co-option, generating heterogeneous microvascular patterns, often associated with microvascular proliferations (MVPs). The transition from an intact blood-brain barrier (BBB) to a dysfunctional blood-brain tumor barrier (BBTB) involves progressive disruption of the neurovascular unit (NVU), yet the phenotypic identity of tumor-associated endothelial cells (ECs) remains poorly characterized.

Methods

We investigated the endothelial phenotype in 22 adult-type diffuse gliomas (glioblastoma, astrocytoma grade 4 and 3, oligodendroglioma grade 3 and 2) by

SUBMITTER: Mora A 

PROVIDER: S-EPMC12486580 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature