Safety and pathological impact of resection after high-dose PBT for locally advanced pancreatic cancer.

ABSTRACT:

Background

A multidisciplinary approach is essential for treating lethal pancreatic cancer. Proton beam therapy (PBT), with its potential for dose escalation, shows promising effect for the local tumor, but the safety of subsequent resection and its pathological impact remain uncertain.

Methods

A retrospective single-center analysis was conducted on patients with locally advanced pancreatic cancer who underwent multidisciplinary treatment, including PBT, chemotherapy and hyperthermia (January 2014 to December 2022). PBT target dose was 67.5 Gy concurrently gemcitabine infusion and local hyperthermia was applied 1 h after gemcitabine infusion. The standard chemo regimens (such as gemcitabine with nab-paclitaxel or FOLFIRINOX) followed triple-modal treatment. Surgical complica

SUBMITTER: Shimomura O 

PROVIDER: S-EPMC12486620 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature