First trimester maternal serum MicroRNA expression and pre-eclampsia: a retrospective nested case-control study.

ABSTRACT:

Background

Numerous circulating microRNAs (miRNAs) have been detected in maternal blood. Initial studies in third trimester demonstrated differential miRNA expression profiles between uncomplicated pregnancies and pregnancies complicated by pre-eclampsia (PE). Recently, studies in first trimester have shown similar differential profiles, however, these studies were often under-powered.

Methods

We conducted a nested case-control study, in which serum samples, taken between 10 and 14 weeks gestation, were obtained from 413 singleton pregnant women, 126 of which later developed PE. Total RNAs were purified and a selection of 46 miRNAs plus two miRNA controls were quantitated by real time quantitative PCR.

Results

Seven of the miRNAs, hsa-miR-181b-5p, -323a-3p, -518b, -36

SUBMITTER: Hedley PL 

PROVIDER: S-EPMC12486713 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature