Dataset Information
Sodium butyrate targets VWF to inhibit cigarette smoke extract-induced endothelial cell-macrophage crosstalk in regulating inflammatory response.
Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC12486758 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
Publications
Sodium butyrate targets VWF to inhibit cigarette smoke extract-induced endothelial cell-macrophage crosstalk in regulating inflammatory response.
Respiratory research 20250930 1
Previous studies have shown that cigarette smoke-induced inflammation is a key driver of chronic obstructive pulmonary disease (COPD) progression. Sodium butyrate (NaB), a short-chain fatty acid that can be endogenously produced or exogenously supplemented, has been reported to exhibit anti-inflammatory effects. This study investigated the therapeutic effects and mechanisms of NaB in cigarette smoke extract (CSE)-induced inflammation. Through network pharmacology analysis, von Willebrand factor ...[more]
