Garlic essential oil alleviate oxidative stress, inflammation and microbiota dybiosis from small intestinal damage in lipopolysaccharide-challenged weaned piglets.

ABSTRACT: This study evaluated the effects of garlic essential oil (GO) supplementation on growth performance, immunity, antioxidant capacity, and small intestine health in weaned piglets. Piglets fed 1 g/kg GO exhibited significantly higher final body weight and average daily gain, coupled with reduced feed-to-gain ratio, indicating enhanced growth performance. In contrast, 0.5 g/kg GO showed no effect, while 1.5 g/kg negatively impacted feed intake and final weight. Immunologically, 1 g/kg GO reduced serum TNF-α and MDA levels, improved jejunal SOD activity, and enhanced antioxidant gene expression (Sod1, Gpx1). Morphologically, 1 g/kg GO increased jejunal villus height and villus-to-crypt ratio while upregulating tight-junction proteins (Zo-1, Claudin-1). After LPS challenge, GO reduced diarrhea

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12486787 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature