Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in <i>Mycobacterium tuberculosis</i>.

ABSTRACT: New anti-tuberculosis (TB) drugs with novel modes of action are in great demand due to the complex treatment regimens as well as the rising number of multidrug-resistant TB cases. We recently re-evaluated a few 2,5,6-trisubstituted benzimidazole derivatives (SBZ) previously demonstrated to have potent antitubercular activity. These compounds displayed favorable MICs and significantly reduced bacterial counts in an acute mouse infection model. Although this antitubercular lead series was initially reported to inhibit mycobacterial cell division, our findings suggest that its primary activity likely involves other cellular targets. By using bacterial cytological profiling, we observed that SBZ-treated Mycobacterium tuberculosis cells exhibit cell wall-damaging phenotypes resembling th

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12486814 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature