Cardiovascular disease and diagnosis of advanced prostate cancer.

ABSTRACT:

Introduction

Cardiovascular disease (CVD) and cancer are the two leading causes of death in the US. Preclinical models support a direct effect of cardiovascular disease (CVD) on accelerated cancer growth and spread. Our objective is to test the hypothesis that individuals with prevalent CVD are at an increased risk of presenting with more advanced prostate cancer at diagnosis.

Methods

We conducted a case-control study in the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked databases from 2010-2019. The analysis was undertaken from October 2024 to February 2025. We included male individuals aged ≥ 67 years diagnosed with invasive prostate cancer with at least two healthcare interactions and evidence of PSA screening in the 3 to 24 months prior to cancer diag

SUBMITTER: Nead KT 

PROVIDER: S-EPMC12486819 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature