Safety, pharmacokinetics, and pharmacodynamics of human interferon-α2b spray in healthy participants.

ABSTRACT: The safety, pharmacokinetics (PK), and pharmacodynamics (PD) of multiple doses of human interferon (IFN)-α2b spray administered via nasal and oropharyngeal routes were evaluated in a randomized, double-blind, placebo-controlled study. Forty-eight healthy Chinese participants were randomized into three dose groups: low (450,000 IU/dose), medium (600,000 IU/dose), and high (750,000 IU/dose). In each group, 12 participants received the corresponding dose of IFN-α2b spray, and four participants received the placebo. All participants received a single nasal and oropharyngeal dose at 0 and 48 h, respectively, with the high-dose group receiving an additional topical abdominal skin dose at 96 h to assess skin irritation. Adverse events were observed and recorded throughout the trial. Plasma, nasal

SUBMITTER: Zhang W-r 

PROVIDER: S-EPMC12486823 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature