Relation of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio to residual risk in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF Project III cohort.

ABSTRACT:

Background

Atrial fibrillation (AF) confers a high risk of thromboembolism and cardiovascular events, which persists despite optimal oral anticoagulation (OAC). The non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio (NHHR) integrates pro- and anti-atherogenic lipid fractions and has been linked to adverse outcomes in high-risk patient populations. The prognostic value of NHHR in anticoagulated AF patients is uncertain. We aimed to evaluate NHHR as a marker of residual thromboembolic and cardiovascular risk in this population.

Methods

Consecutive AF outpatients initiating OAC between January 2016 and November 2021 were enrolled in this prospective cohort study. NHHR was calculated from baseline non-HDL-C and HDL-C levels

SUBMITTER: Soler-Espejo E 

PROVIDER: S-EPMC12486827 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature