Allelopathic compound 2-methoxy-1,4-naphthoquinone is broadly effective against pathogenic <i>Prototheca</i> species <i>in vitro</i> and <i>in vivo</i>.

ABSTRACT: Unpigmented, yeast-like Prototheca algae are emerging pathogens responsible for unusual infections in humans and animals. Their treatment is often unsuccessful, as traditional antifungals and antibacterials show unsatisfactory activity against Prototheca. Therefore, the development of improved drugs that consider the peculiarities of algal biology is needed. Here, we describe a novel anti-Prototheca compound, the 2-methoxy-1,4-naphthoquinone, identified among molecules known to mediate plant and algal allelopathy. The 2-methoxy-1,4-naphthoquinone was highly active in vitro against a range of Prototheca isolates from different species, both planktonically and in biofilms. Its mode of action included the induction of toxic reactive oxygen species, and it ta

SUBMITTER: Aliramezani A 

PROVIDER: S-EPMC12486852 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature