Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressing <i>Mycobacterium smegmatis</i>.

ABSTRACT: β-lactams demonstrate promising in vitro activity against Mycobacterium species and are being explored for tuberculosis treatment; however, evidence of their in vivo efficacy versus Mycobacterium tuberculosis remains limited. To achieve broad clinically relevant potency, optimization of the classical β-lactam scaffolds or development of new or non-β-lactam inhibitors for mycobacterial transpeptidases is likely required. In mycobacteria, potential targets of β-lactams include l,d-transpeptidases (Ldts) and penicillin-binding proteins (PBPs). Reports suggest that dual inhibition of Ldts and PBPs may be necessary to achieve effective anti-mycobacterial activity, yet the specific contributions of Ldt and PBP inhibition to the β-lactam antibacterial mechanisms are po

SUBMITTER: de Munnik M 

PROVIDER: S-EPMC12486854 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature