Epidemiology and outcomes associated with brain metastases among patients with metastatic breast cancer - a cohort study in US electronic health record data.

ABSTRACT:

Background

There are limited real-world data on the prevalence of brain metastases (BM) in metastatic breast cancer (mBC) across the treatment pathway, especially when stratified by human epidermal growth factor receptor 2-positive (HER2+) or HER2-negative (HER2-) status. The goals of this study were to estimate the prevalence of BM at metastatic diagnosis and at the start of each line of systemic therapy (LOT), and to describe treatment patterns and overall survival (OS) in patients with and without BM.

Methods

This retrospective cohort study included adult patients in the US with mBC diagnosed between January 2013 - May 2020, with known HER2 status from an electronic health record-derived, deidentified database. Patients were followed from mBC diagnosis to last activity da

SUBMITTER: Varghese D 

PROVIDER: S-EPMC12486881 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature