Intracranial pressure is elevated at 24 h post-stroke in mice.

ABSTRACT:

Background

It has long been assumed that post-stroke intracranial pressure (ICP) elevation occurs because of large infarct and edema volumes. However, we have repeatedly shown ICP elevation at 24 h post-stroke in the presence of little to no edema in rats. Biological processes are often conserved across species and types of injury. Therefore, we aimed to determine if an ICP rise occurs at 24 h post-stroke in the presence of small infarct and edema volumes in mice.

Methods

Mice were randomized by random number table to either photothrombotic stroke or sham surgery (n = 15). Epidural ICP was recorded using a fiber optic catheter at 1 h post-stroke (baseline) and between 23 and 24 h post-stroke.

Results

ICP was significantly higher at 24 h compared to baseline in

SUBMITTER: Warren KE 

PROVIDER: S-EPMC12486897 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature