Long-term body mass index trajectories and dyslipidemia and related gut microbial features: results from the China health and nutrition survey 1991-2018.

ABSTRACT:

Objective

To discover the associations between long-term body mass index (BMI) trajectories and dyslipidemia, and the internal mechanism within different BMI trajectory populations.

Methods

We chose 11,499 adults from China Health and Nutrition Survey (CHNS) for trajectory modeling. Selected those with two blood lipid measurements (n = 2,003), and determine the risk trajectory group associated with dyslipidemia. We selected two subsets of the 2015 CHNS, CHNS-1 (n = 3,061) and CHNS-2 (n = 1,409) for gut microbiome analysis. A Lasso regression in both the CHNS-1 and the CHNS-2 confirmed the dominant genera of each dyslipidemia risk trajectory. We also used a subset of CHNS-2 (n = 779) with metabolomics data to identify the differential metabolites. We ascertained the connectio

SUBMITTER: Guan F 

PROVIDER: S-EPMC12486964 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature