Deciphering the origins of guanylate-binding proteins in mammals (Monotreme, Marsupials and Placentals).

ABSTRACT:

Background

Guanylate-binding proteins (GBPs) belong to the large guanosine triphosphatases (GTPases) family and have specialised in host defence in vivo against a broad spectrum of invading pathogens. This ancient evolutionary group of genes was first studied in humans and rodents, but its evolution remained largely unknown for nearly 20 years. In recent years, more studies have emerged deepening the knowledge of GBP evolution in specific mammalian groups: Primates, Tupaia, Muroids (Rodents), Bats and Lagomorphs.

Results

Here, we aimed to present a comprehensive analysis of mammals GBP evolution. Our phylogenetic analysis demonstrates that mammals' GBPs share a common ancestor and that each major mammalian group has evolved a specific GBP repertoire. Two Monotreme GBP groups

SUBMITTER: Corte-Real JV 

PROVIDER: S-EPMC12486975 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature