Magnetically navigated nano-PROTAC ameliorates acute lung injury.

ABSTRACT:

Introduction

Acute lung injury (ALI) is an acute inflammatory lung disease with high rates of morbidity and mortality. The lack of efficient pharmacological treatments for ALI resulted in poor outcomes and prognosis.

Methods

Poly(lactic-co-glycolic acid) (PLGA) was used to carry magnetic nanoparticles and TRIM24-targeted PROTAC (dTRIM24), which was further camouflaged with the exosome membranes derived from M1 macrophages to obtain nano-PROTAC (EM/PLGA/Magnetic nanoparticles/dTRIM24, EMPLANT). We evaluated the nanoparticles on the physicochemical properties, cellular uptake, in vitro toxicity, anti-inflammatory effects, in vivo biodistribution, in vivo therapeutic effect, anti-inflammatory capacity, and in vivo safety.

Results

This nano-PROTAC EMPLANT, shows dual-targ

SUBMITTER: Chen S 

PROVIDER: S-EPMC12486976 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature