Dataset Information
PSMA-targeted theranostic nanoplatform achieves spatiotemporally precise therapy and triggers ferroptosis in prostate cancer treatment.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC12487002 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
Publications
PSMA-targeted theranostic nanoplatform achieves spatiotemporally precise therapy and triggers ferroptosis in prostate cancer treatment.
Journal of experimental & clinical cancer research : CR 20250930 1
BACKGROUND: Ferroptosis, an iron-dependent form of regulated cell death, is crucial for the fate of tumors such as prostate cancer (PCa) under conditions of metabolic and oxidative stress. Consequently, the disruption of ferroptosis defense mechanisms could be lethal to these cancer cells, while sparing normal cells. Despite this potential, the development of effective and controlled in vivo therapies targeting ferroptosis remains underexplored. METHODS: In this study, liposomes modified with Gl ...[more]