Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization.

ABSTRACT:

Background

Migraine is a highly prevalent neurological disorder with complex pathophysiology and limited treatment efficacy. Emerging evidence suggests immune cell involvement in migraine, but the specific regulatory mechanisms remain unclear. This study aimed to identify immune cell-type-specific genetic drivers of migraine and prioritize potential therapeutic targets.

Methods

We conducted a Mendelian randomization (MR) analysis integrating single-cell expression quantitative trait loci (sc-eQTL) data from 14 immune cell types with large-scale genome-wide association studies (GWAS) of migraine. Colocalization analysis, protein-protein interaction (PPI) networks, linkage disequilibrium score regression (LDSC), phenome-wide association studies (PheWAS), and drug repurposing d

SUBMITTER: Hong Y 

PROVIDER: S-EPMC12487071 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature