Structural and hormonal changes in the ovaries of women with polycystic ovary syndrome and healthy controls: a 13-year prospective study in an unselected population.

ABSTRACT:

Background

This study investigates whether ovarian structural and hormonal changes over a 13-year period differ between women diagnosed with polycystic ovary syndrome (PCOS) and healthy controls within an unselected population.

Methods

This prospective nested cohort study followed up on a prevalence study conducted in 2009 in an unselected-population. A total of 41 women with PCOS (≥ 35 years-old, diagnosed using the Rotterdam criteria) and 43 age- and body-mass-index-(BMI)-matched healthy controls were included from this cohort. The relationship between ovarian structure and hormonal profiles was tracked over 13 years. Antral follicle count (AFC) and ovarian volume (OV) were assessed by transvaginal/pelvic ultrasonography. Anti-Mullerian hormone (AMH), total testosterone (T

SUBMITTER: Sonu NC 

PROVIDER: S-EPMC12487078 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature