High-order single-nucleotide polymorphism interactions between selected anti-oxidant and protease genes influence North Indians' propensity for chronic obstructive pulmonary disease (COPD) and lung function parameters.

ABSTRACT:

Background

COPD causes persistent airflow restriction, oxidative stress, and inflammation. Proteins like MMP9, MMP12, and ADAM33, and antioxidant enzymes such as Glutathione Peroxidase, Superoxide Dismutase, and Catalase are crucial for lung homeostasis, and imbalances increase COPD risk.

Methods

A case-control study was carried out with 500 healthy controls and 500 COPD patients. We did genotype on several SNPs in CAT, SOD1, SOD2, GPx, MMP9, MMP12, and ADAM33, and further MDR, CART, and logistic regression models were applied to examine gene-gene interactions, pulmonary function tests, and clinical symptoms.

Results

SNPs associated with higher COPD risk were SOD2 rs4880, CAT rs1001179, MMP9 rs17576, and ADAM33 rs612709. High-order combinations like SOD2 rs4880 and AD

SUBMITTER: Kansal H 

PROVIDER: S-EPMC12487100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature