Variation in metabolic pattern regulation under hypoxic conditions: a comparative study of rodents distributed at different altitudes.

ABSTRACT: Mammals dwelling at different altitudes exhibit distinct molecular mechanisms to adapt to low-oxygen environments owing to habitat-specific oxygen levels. Notably, these adaptations include energy metabolism patterns, which fundamentally sustain vital physiological functions. Skeletal muscle, a pivotal contributor to systemic energy metabolism, facilitates vertebrate body movement through the contraction and relaxation of muscle fibers and is highly dependent on mitochondrial substrate oxidation for energy production. This study focused on three rodent species inhabiting different altitudes: the Qinghai vole (Neodon fuscus), Brandt's vole (Lasiopodomys brandtii), and Kunming mouse (Mus musculus). Using transcriptomics and quasi-targeted metabolomics, we systematically analyzed the differen

SUBMITTER: Li M 

PROVIDER: S-EPMC12487112 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature