Hypertensive disorders of pregnancy were more strongly associated with the functional and network profiles than with the community composition of the gut bacteriome: a pilot study.

ABSTRACT:

Background

Recent studies implicate that hypertensive disorders of pregnancy (HDP) is associated with gut microbiome. However, the different associations of different microbial features with HDP are little known. This study investigates the different associations of gut bacterial taxonomic composition, functional and network profiles with HDP.

Methods

A case-control study was conducted in Hefei Maternal and Child Health Hospital from February to August 2024. Twenty-four women with HDP and twenty-one normotensive pregnant controls were included. Fecal samples were collected and the bacterial community in fecal samples were measured using high-throughput sequencing targeting the V4 region of the bacterial 16 S rRNA. The taxonomic composition, functional and network profiles of

SUBMITTER: Li L 

PROVIDER: S-EPMC12487138 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature