Interplay of axon regeneration genes and immune infiltration in spinal cord injury.

ABSTRACT:

Background

Spinal Cord Injury (SCI) impacts neural function and regeneration. This study aimed to identify key axon regeneration genes in SCI and their correlations with immune infiltration and SCI subtyping.

Methods

Gene expression profiles of 30 sham-operated mice and 29 SCI mice were obtained from GSE5296, GSE47681, and GSE93561 datasets. A PPI network of axon regeneration genes was constructed. Consensus clustering classified SCI subtypes. Differential expression analysis identified genes associated with SCI and its subtypes. Immune infiltration was assessed. WGCNA identified key genes. Potential drugs targeting hub genes were explored. An SCI mouse model was established and subjected to HE staining to assess pathological changes. The dysregulation of five key axon regen

SUBMITTER: Xiang Z 

PROVIDER: S-EPMC12487177 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature