Bronchoalveolar lavage proteomics in exacerbation of bronchiectasis.

ABSTRACT:

Background

The molecular pathophysiology underlying the development of bronchiectasis with exacerbation at the proteomic level has not been clarified using bronchoalveolar lavage fluid samples. This study aimed to evaluate the bronchoalveolar lavage fluid inflammatory profiles associated with exacerbation of bronchiectasis.

Methods

We analyzed the bronchoalveolar lavage fluid specimens from 4 patients in the exacerbation status and 4 patients in a stable status using liquid chromatography-tandem mass spectrometry.

Results

A total of 1,577 proteins were identified using proteomic analysis, with 127 differentially expressed proteins. Of 127 differentially expressed proteins, 23 proteins showed more than 2-fold differences between exacerbation and stable status groups. T

SUBMITTER: Lee JY 

PROVIDER: S-EPMC12487217 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature