Dietary polyunsaturated fatty acid intake and all-cause and cardiovascular mortality in patients with COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) patients face increased mortality risk, particularly from cardiovascular causes. While polyunsaturated fatty acids (PUFAs) have shown cardiovascular benefits in general populations, their impact on COPD mortality remains unexplored.

Methods

This prospective cohort study analyzed 2,102 COPD patients from NHANES (1999-2018). PUFA intake was assessed through 24-hour dietary recalls and categorized into tertiles. Associations with all-cause and cardiovascular mortality were evaluated using Cox regression models, restricted cubic splines (RCS), and weighted quantile sum (WQS) regression. Comprehensive subgroup and sensitivity analyses confirmed result robustness.

Results

During 9.08 years of follow-up, 603 deaths (28.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12487311 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature