Effect of an antibiotic and a probiotic on phage communities in the swine gut microbiota.

ABSTRACT:

Objective

The impact of dietary treatments on the phage community of porcine intestinal microbiota is not well understood. An antibiotic (tylvalosin), a probiotic (Pediococcus acidilactici), and a combination of these were given to six cannulated pigs in a double crossover design study. Samples of ileal digesta and feces were collected and whole genome shotgun sequencing was performed. The variations in phage and bacterial communities were compared for each treatment and sample type.

Results

The bacteriophages present in the gut microbiome exhibited greater variations in both α- and β-diversity between sample types (digesta, feces) than between treatments. β-diversity and differential abundance showed that the effect of the combined antibiotic and probiotic treatment was the

SUBMITTER: Lemieux E 

PROVIDER: S-EPMC12487356 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature